Figure 1 shows meta analyses of a selective COX 2 inhibitor versus placebo, subdivided by individual selective COX 2 inhibitor, for each of the primary outcomes. Overall, among 121 placebo controlled trials, 216 vascular events occurred during 18 490 person years of exposure to a selective COX 2 inhibitor (1.2%/year) compared with 112 during 12 639 person years of placebo (0.9%/year), corresponding to a 42% proportional increase in the incidence of a first serious vascular event (rate ratio 1.42, 95% confidence interval timberland boots for kids
1.13 to 1.78; P = 0.003). We found no evidence that the proportional excess incidence of vascular events varied among the different selective COX 2 inhibitors (heterogeneity 2 = 0.5, df = 4; P = 1.0). However, as only two selective COX https://en.wikipedia.org/wiki/The_Timberland_Company 2 inhibitors (rofecoxib and celecoxib) had recorded appreciable numbers of such outcomes, the power to identify any real differences that might exist between selective COX 2 inhibitors was limited. In the group of trials analysed, this proportional difference corresponded to an excess of 3 (95% timberland shoes for men 2015
confidence interval 1 to 5) timberland boots for women with spikes
people with a vascular event per 1000 allocated to a selective COX 2 inhibitor per year.
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