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Figure 1 shows meta analyses of a selective COX 2 inhibitor versus placebo, subdivided by individual selective COX 2 inhibitor, for each of the primary outcomes. Overall, among 121 placebo controlled trials, 216 vascular events occurred during 18 490 person years of exposure to a selective COX 2 inhibitor (1.2%/year) compared with 112 during 12 639 person years of placebo (0.9%/year), corresponding to a 42% proportional increase in the incidence of a first serious vascular event (rate ratio 1.42, 95% confidence interval timberland boots for kids
1.13 to 1.78; P = 0.003). We found no evidence that the proportional excess incidence of vascular events varied among the different selective COX 2 inhibitors (heterogeneity 2 = 0.5, df = 4; P = 1.0). However, as only two selective COX https://en.wikipedia.org/wiki/The_Timberland_Company 2 inhibitors (rofecoxib and celecoxib) had recorded appreciable numbers of such outcomes, the power to identify any real differences that might exist between selective COX 2 inhibitors was limited. In the group of trials analysed, this proportional difference corresponded to an excess of 3 (95% timberland shoes for men 2015
confidence interval 1 to 5) timberland boots for women with spikes
people with a vascular event per 1000 allocated to a selective COX 2 inhibitor per year.

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The print edition of the Financial Times has a smaller circulation than Helsingin Sanomat rather more than 300,000 but the paper’s online version is read by millions of financial decision makers all over the world, so the publicity could have an impact on those who don’t know much about the place beforehand.